翟李欣，女，工学博士，1991年10月生于河南省许昌市。主要从事分子酶学与合成生物学等领域研究。

邮箱：zhailixin216831@163.com

学习/工作经历：

2010.09至2014.06 黑龙江大学 制药工程（生物制药）专业 (学士)

2014.09至2017.06 黑龙江大学 微生物学专业，微生物制药方向 (硕士)

2017.09至2021.06 江南大学 发酵工程专业，基因工程与酶工程方向 (博士)

2021.07至2023.06 上海交通大学 研究助理

2023.07至今 我院 8868体育入口登录，讲师

主要研究方向：

1）生物酶的挖掘及其生化特性研究；

2）酶分子改造及其催化机理解析；

3）化学药物中间体及生物药疫苗的生物催化合成工艺开发

代表性研究论文:

1. Lixin Zhai, Runxian Ren, Di Meng, Qiaopeng Tian, Zhengbing Guan, Yujie Cai, Xiangru Liao. Comparison of aminotransferases of three Bacillus strains Bacillus altitudinis W3, Bacillus velezensis SYBC H47, and Bacillus amyloliquefaciens YP6 via genome analysis and bioinformatics [J]. Journal of Applied Genetics, 2019, 60 (3-4): 427-430.

2. Lixin Zhai, Shaolan Yang, Yingjie Lai, Di Meng, Qiaopeng Tian, Zhengbing Guan, Yujie Cai, Xiangru Liao. Mining of aminotransferase gene ota3 from Bacillus pumilus W3 via genome analysis, gene cloning and expressing for compound bioamination [J]. Gene, 2019, 686: 21-28.

3. Lixin Zhai, Shaolan Yang, Yingjie Lai, Di Meng, Qiaopeng Tian, Zhengbing Guan, Yujie Cai, Xiangru Liao. Effect of residue substitution via site-directed mutagenesis on activity and steroselectivity of transaminase BpTA from Bacillus pumilus W3 for sitafloxacin hydrate intermediate [J]. International Journal of Biological Macromolecules, 2019, 137: 732-740.

4. Lixin Zhai, Zihao Xie, Qiaopeng Tian, Zhengbing Guan, Yujie Cai, Xiangru Liao. Structural and Functional Analysis of the Only Two Pyridoxal 5’-Phosphate-Dependent Fold Type IV Transaminases in Bacillus altitudinis W3 [J]. Catalysts, 2020, 10: 1308.

5. Di Meng, Lixin Zhai, Qiaopeng Tian, Zhengbing Guan, Yujie Cai, xiangru Liao. Complete genome sequence of Bacillus amyloliquefaciens YP6, a plant growth rhizobacterium efficiently degrading a wide range of organophosphorus pesticides [J]. Journal of Integrative Agriculture, 2019, 18 (11): 2668-2672.

6. Shaolan Yang, Lixin Zhai, Lin Huang, Di Meng, Jing Li, Zhikui Hao, Zhengbing Guan, Yujie Cai, xiangru Liao. Mining of alkaline proteases from Bacillus altitudinis W3 for desensitization of milk proteins: Their heterologous expression, purification, and characterization [J]. International Journal of Biological Macromolecules, 2020, 153: 1220-1230.

7. Zihao Xie, Lixin Zhai, Di Meng, Qiaopeng Tian, Zhengbing Guan, Yujie Cai, Xiangru Liao. Improving the catalytic thermostability of Bacillus altitudinis W3 ω‑transaminase by proline substitutions [J]. 3 Biotech, 2020, 10: 323.

8. Runxian Ren, Lixin Zhai, Qiaopeng Tian, Di Meng, Zhengbing Guan, Yujie Cai, xiangru Liao. Identification of a novel glycerophosphodiester phosphodiesterase from Bacillus altitudinis W3 and its application in degradation of diphenyl phosphate [J]. 3 Biotech, 2021, 11: 161.

9. 翟李欣, 徐慧超, 李伟, 等，东北膜荚黄芪内生细菌的分离及其活性代谢物分析[J]. 中国食品学报, 2019, 19(03):299-305.

10. 翟李欣，杨鹏，张萍，等，三种中草药提取物对北虫草细胞生长及活性产物形成的影响[J]. 中国食品学报, 2017, 17(03):157-162.

已授权发明专利：

1. 廖祥儒，翟李欣，等，一种催化效率提高的ω-转氨酶突变体及其应用. 专利号：201811450486.3

2. 廖祥儒，翟李欣，等，一种催化效率提高的ω-转氨酶突变体. 专利号：201811350818.0

3. 廖祥儒，翟李欣，等，一种可催化西他沙星五元环中间体的ω-转氨酶突变体. 专利号：201811449183.X

4. 廖祥儒，翟李欣，等，一种能催化西他沙星五元环关键中间体的ω-转氨酶突变体. 专利号：201811449438.2

5. 廖祥儒，翟李欣，等，一种可催化西他沙星五元环关键中间体的ω-转氨酶突变体. 专利号：201811449197.1

6. 廖祥儒，翟李欣，等，一种催化效率提高的ω-转氨酶突变体I215F. 专利号：201811449478.7

7. 廖祥儒，翟李欣，等，一种能够催化西他沙星五元环中间体的ω-转氨酶突变体. 专利号：201811449434.4

8. 廖祥儒，翟李欣，等，一种来自短小芽孢杆菌的ω-转氨酶及在生物胺化中的应用. 专利号：201811219769.7